A 59-game slate kicks off Thursday with Temple at USF. Some big games this week send highly-ranked teams on the road to face worthy opponents.
Penn State visits Iowa, Alabama heads to Vanderbilt, Oklahoma State entertains TCU, Washington is at Colorado, Michigan travels to Purdue, and Georgia hosts Mississippi State.
The week also features Notre Dame at Michigan State, UCLA at Stanford, Syracuse at LSU, and San Diego State at Air Force.
Get the computer's pick of every game here.