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Changes to the schedule this week:
Louisville at Virginia moved to November 14.
Purdue at Wisconsin canceled. Covid issues at Wisconsin.Will not be made up.
FIU at UTEP canceled. 4th FIU game canceled due to Covid.
Tulsa at Navy postponed due to Covid issues at Navy.
Air Force at Army postponed due to Covid cases at Air Force.
Washington at California canceled due to Covid/contact tracing issue at Cal and Will not be made up.
Louisiana Tech at North Texas postponed. Covid issues at North Texas. Moved to December 3.
Charlotte at MTSU postponed. Covid issues at Charlotte.
UTSA at Rice. Covid issues at UTSA.
Arizona at Utah. Covid issues at Utah. Will not be made up.
* All times Eastern
* FBS Rankings reflect the AP Poll
| Time | Game | Network |
| Thursday, November 5 |
||
| 7:00 p.m. | Utah State at Nevada | FS1 CBSSN |
| 9:00 p.m. | Wyoming at Colorado State | CBSSN |
| Friday, November 6 | ||
| 7:30 p.m. | (11) Miami (FL) at NC State | ESPN |
| 9:00 p.m. | San Jose State at San Diego State | CBSSN |
| 9:45 p.m. | (9) BYU at (21) Boise State | FS1 |
| Saturday, November 7 | ||
| Noon | (23) Michigan at (13) Indiana | FS1 |
| Noon | (18) SMU at Temple | ESPN+ |
| Noon | Arizona State at (20) USC | FOX |
| Noon | West Virginia at (22) Texas | ABC |
| Noon | (25) Liberty at Virginia Tech | ACCN |
| Noon | USF at Memphis | ESPN+ |
| Noon | Tulane at East Carolina | ESPN+ |
| Noon | North Carolina at Duke | ESPN2 |
| Noon | UL Monroe at Georgia State | ESPN3 |
| Noon | Nebraska at Northwestern | BTN |
| Noon | Michigan State at Iowa | ESPN |
| Noon | Arkansas State at Louisiana | ESPNU |
| 1:00 p.m. | Troy at Georgia Southern | ESPN3 |
| 2:00 p.m. | Boston College at Syracuse | ESPN3/RSN |
| 2:30 p.m. | UMass at (16) Marshall | ESPN+ |
| 3:00 p.m. | North Alabama at Southern Miss | ESPN3 |
| 3:00 p.m. | Appalachian State at Texas State | ESPN+ |
| 3:30 p.m. | (8) Florida vs. (5) Georgia (Jacksonville, FL) | CBS |
| 3:30 p.m. | Houston at (6) Cincinnati | ABC |
| 3:30 p.m. | Kansas at (19) Oklahoma | ESPN |
| 3:30 p.m. | Maryland at Penn State | BTN |
| 3:30 p.m. | Minnesota at Illinois | BTN |
| 3:30 p.m. | Vanderbilt at Mississippi State | SECN |
| 3:30 p.m. | Texas Tech at TCU | FS1 |
| 3:30 p.m. | Fresno State at UNLV | CBSSN |
| 4:00 p.m. | (14) Oklahoma State at Kansas State | FOX |
| 4:00 p.m. | Pittsburgh at Florida State | ACCN |
| 6:00 p.m. | Western Kentucky at FAU | Stadium |
| 7:00 p.m. | (7) Texas A&M at South Carolina | ESPN |
| 7:00 p.m. | Baylor at (17) Iowa State | FS1 |
| 7:00 p.m. | UCLA at Colorado | ESPN2 |
| 7:30 p.m. | (1) Clemson at (4) Notre Dame | NBC |
| 7:30 p.m. | Rutgers at (3) Ohio State | BTN |
| 7:30 p.m. | Stanford at (12) Oregon | ABC |
| 7:30 p.m. | Tennessee at Arkansas | SECN |
| 8:00 p.m. | South Alabama at (15) Coastal Carolina | ESPNU |
| 10:30 p.m. | Washington State at Oregon State | FS1 |
| 11:00 p.m. | New Mexico at Hawai'i | Spectrum PPV/Team1 Sports |
| Tuesday, November 10 | ||
| 7:00 p.m. | Akron at Ohio | CBSSN |
| 7:30 p.m. | Kent State at Bowling Green | ESPN2 |
| 8:00 p.m. | Miami (OH) at Buffalo | ESPN |
| Wednesday, November 11 | ||
| 7:00 p.m. | Eastern Michigan at Ball State | CBS Sports Network |
| 8:00 p.m. | Toledo at Western Michigan | ESPN |
| 8:00 p.m. | Central Michigan at Northern Illinois | ESPNU |